A mutation in the Gsk3-binding domain of zebrafish masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon
Article Abstract:
Research reveals that masterblind protein mutants of zebrafish embryos exhibit an amino-acid substitution in the Wnt pathway protein Axin1that prevents Axin1 binding to Gsk-3. Data demonstrate that this Axin1-dependent inhibition of Wnt pathway plays a role in the early differentiation of anterior neural plate.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
Article Abstract:
The usage of genetic analysis indicates that the zebrafish iguana gene product acts downstream of the smoothened protein to modulate Gli activity in the somites of the developing embryo. The positional cloning reveals that iguana encodes the zebrafish ortholog of Dzipl, a novel zinc-finger/coiled-coil domain protein, which can shuttle between the cytoplasm and nucleus in a manner correlated with Hedgehog pathway activity.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/[beta]catenin and Wnt/PCP activities, through interaction with the Dally-like homolog knypek
Article Abstract:
A study was conducted to address the role of Dickkopf-1 (Dkk1) in the mesendoderm during gastrulation, which is thought to act through vertical signaling from the anterior mesendoderm. The result data indicate that Dkk1 regulates gastrulation movement through interaction with LRP5/6 and Kny and coordinated modulations of Wnt/[beta]catenin and Wnt/planar cell polarity pathways.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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